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Cooltime (Alprazolam)

To evaluate the efficacy of a mild anxiolytic, Cooltime, in relieving dyspnea, we conducted a randomized, placebo-controlled double-blind study on patients with chronic obstructive lung disease. The study demonstrated that Cooltime was superior to placebo and equipotent to primidone, whereas there was no statistically significant difference between acetazolamide and placebo.

Other names for this medication:
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Cooltime is used to treat anxiety and panic disorders. It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body (GABA).

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To explore the regulatory effects of Egr-1 promoter sequences in transcriptional targeting by 5-fluorouracil(5-Fu) on the expression of hematopoietic growth factor genes. We conclude that children with HSP nephritis even with isolated microscopic hematuria and/or mild proteinuria should be followed closely. Significantly increased amounts of sE-selectin serum levels were found in psoriatic patients as compared to healthy controls. Transient coexpression of Rx and cytoplasmically localized RanGAP2 sequesters Rx in the cytoplasm.

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Quantitative determination of 20-hydroxyecdysone in methanolic extract of twigs from Vitex polygama Cham. Surveillance of patients with a history of cancer is a frequent practice in oncology.

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Anomalous coronary arteries in patients undergoing repair of right ventricular outflow obstruction: report of three cases Current asthma guidelines emphasize domains of impairment and risk for assessing severity and control, noting the need to consider separately the effects of asthma on asthma quality of life and functional capacity.

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The pattern of cytokeratin expression provides further evidence that tumours with a specific myoepithelial phenotype occur rarely in the breast. These results suggest that, when the enzyme binds to 5-azacytosine in the presence of the cofactor, a methyl group is transferred to the N-5 position of the base, resulting in the inactivation of the enzyme.

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Inaccurate self-reporting is the primary threat to the validity and utility of self-report in the research on illicit drug use. Heart failure and chronic obstructive pulmonary disease: lung function test interpretation. Trainee medical parasitologists can obtain higher degrees locally or abroad. Evidence of differentiated keratin peptide (K1) in cultured human squamous cell carcinomas: demonstration of generality by three different approaches. Triplex-forming oligodeoxynucleotides targeting survivin inhibit proliferation and induce apoptosis of human lung carcinoma cells.

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Environmental challenges during the prenatal period can result in behavioral abnormalities and cognitive deficits that appear later in life such as autism. The present study confirms the importance of Vd as an indispensable reference volume for normalization of Emax, as well as the low sensitivity of Emax Vd as a normalized Emax to changes in Vd/Vm. Scaffolds were analysed for gene expression, DNA content and glycosaminoglycan amount. This prerequisite is mandatory to obtain a sustained improvement in metabolic control.

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To evaluate the methodologic quality of 3 primary open-angle glaucoma (POAG) clinical practice guidelines (CPGs). Similarly to many other autoimmune diseases, multiple sclerosis (MS) is more common among women than men, and its incidence among women is rising.

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Chemical modifications of these heterocycles constantly result in compounds with a wide spectrum of pharmacological activities. Selective homing of autoreactive lymphocytes to the pancreatic islets of Langerhans is essential for triggering the cascade of molecular and cellular interactions which culminate in the specific destruction of the insulin-producing beta-cells. There is even less information available on the use of an interdisciplinary approach for management of sickle cell crisis pain. These data suggest that both the microbial growth on plasterboard and the resulting bioactivity of spores vary and might be affected by changing the growth conditions provided by the plasterboards. Antibodies of IgM type against small cell lung carcinoma and 29 kD neuronal antigen of rat in a patient with paraneoplastic sensory neuropathy

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This approach does not require specific chemical groups on the target surface to initiate ALD. We hypothesized that addressing the 24-h relationship between RR interval and systolic arterial pressure (SAP) during ambulatory blood pressure monitoring could detect alterations in circadian arterial pressure and heart rate profile and could also be linked to the ambulatory arterial stiffness index. Measurements were made of the effects of stimulus bandwidth and type (speech bands versus pure tones) on interfrequency differences at the most comfortable loudness level (MCL).

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Clinical and metabolic characteristics of an obese, Dominican, pediatric population. High sensitivity biosensor measurement based on synchronous detection. Third, what if prior storage at one condition affects the slope at the other condition? A novel binding protein of single immunoglobulin IL-1 receptor-related molecule: Paralemmin-3. Traumatic diaphragmatic rupture: a rare cause of postoperative shortness of breath.

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Electron microscopic reconstructions demonstrated that the soluble monomer of ClyA must undergo large conformational changes to form the transmembrane pore. To address the molecular basis for the inhibition by the natural cofactor (6R)-l-erythro-5,6,7,8-tetrahydrobiopterin, its effects on the recombinant tetrameric human enzyme (wt-hPAH) was studied using three different conformational probes, i.e. In practice, F(E)NO measurements are useful in the management of severe or difficult asthma. Cardiac stress reactions and perseverance: Diminished reactivity is associated with study non-completion.

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Inhibitory effect of Poncirus trifoliate on acetylcholinesterase and attenuating activity against trimethyltin-induced learning and memory impairment. These findings prompted us to investigate the antitumor activity of molecular targeting agents in thyroid cancer cells.

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Reduction of dehydroascorbic acid (DHA) required GSH and was both direct and enzyme dependent. Mother-to-child transmission of HIV in Botswana: an ethical perspective on mandatory testing. In this article, Dr Wineman discusses assessment of colorectal cancer risk and the advantages and disadvantages of the fecal occult blood test, flexible sigmoidoscopy, double-contrast barium enema, and colonoscopy. Imaging and histologic tools are also available for diagnosing and classifying hyperinsulinism. In our in vitro study, we investigated putative antiprogestin activities of the plant compounds apigenin (API) and trans-ferulic acid (t-FA) as well as the UV absorbers octyl methoxycinnamate (OMC) and 4-methylbenzylidene camphor (4-MBC).

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Healthy eating beliefs and intentions of mothers and their adult children: An intergenerational transmission perspective. Present taxonomy is essentially based on their postsynaptic targets, but a physiological counterpart to this classification has not yet been determined.

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Our results show that exogenous SAM (10-50microM) rescues cells from the toxic effects of 6-MP (5microM) by delaying the onset of apoptosis. These results raise the possibility that TGBp2 facilitates intracellular delivery of viral RNA through non-specific protein-RNA interaction.

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Prostate-specific antigen for pretreatment prediction and posttreatment evaluation of outcome after definitive irradiation for prostate cancer. No activation was observed towards p-nitrophenyl acetate (PNPA) at the addition of sodium dodecyl sulfate (SDS) nor in the presence of a solid polystyrene surface. Diacylglycerol kinase (DGK) and protein kinase C (PKC) are two distinct enzyme families associated with diacylglycerol.

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NRs control hepatic processes such as bile acid homeostasis, lipid metabolism and mechanisms involved in fibrosis and inflammation. Absence of recurrence with ciprofloxacin therapy of thrombocytopenia induced by pefloxacin Therefore, surgical management such as extirpation of the obstructive uterine horn is required for treatment of these patients. Full-length immunoglobulin G (IgG) of W1 and W2 efficiently protected rats from anthrax toxin challenge.

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The membrane alterations that occur during blood bank storage are reminiscent of the surface changes which result from platelet secretion: an increased surface concentration of GP IIb-IIIa and GMP-140, and the appearance of platelet membrane microparticles in the supernatant plasma. The deleterious role thought to be played by eosinophils in many situations is linked to their ability to secrete various inflammatory substances, mainly toxic proteins and lipid mediators, in body tissue. While structural and functional alterations in mitochondria (mt) and their metabolites have been implicated in the pathogenesis of chronic neurodegenerative and vascular diseases, the relationship of inherited variants in the mitochondrial genome and mt haplogroup subtypes with advanced AMD has not been reported in large prospective cohorts. An abundant population of small irregular satellites around Jupiter.

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Although certain details of interest are not detectable with digital mammography, DBT can reveal their signal by reducing the complexity of tissue structures. Irritable bowel syndrome: are incentives useful for improving survey response rates?

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Epilepsy is one of the most common and disabling neurologic conditions, yet we have an incomplete understanding of the detailed pathophysiology and, thus, treatment rationale for much of epilepsy. The curative approaches to organ-confined, clinically localized prostate cancer include radiation therapy, radical prostatectomy, and close observation in selected patients. The previously described expression patterns of zebrafish and mouse Hoxa1 genes are seemingly very disparate, with mouse Hoxa1 expressed in the gastrula stage hindbrain and the orthologous zebrafish hoxa1a gene expressed in cell clusters within the ventral forebrain and midbrain.

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A total of 5 HOFs and 1 APN participated in the postintervention test 1 week later. Intravenous bolus administration of a paramagnetic contrast medium is performed after timing of the bolus arrival time, thus enabling rapid acquisition of 3D datasets with high contrast between vessel lumen and surrounding soft tissue. Evidence for cancer stem cells contributing to the pathogenesis of ovarian cancer.

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In this study, it has been aimed to investigate whether neutrophil-lymphocyte ratio (NLR) was higher in non-obese patients with bipolar disorder (BD) than in a healthy control group matched for age, sex, and body mass index, and also to determine if there was an interaction between NLR and severity of the bipolar disorder. Conversion to sirolimus in solid organ transplantation: a single-center experience. The first five minutes represented reference values, whereafter endotoxin E. Granulocyte colony-stimulating factor (G-CSF) exerts various biological effects through occupancy of its receptor (G-CSFR).

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Recently, T-brain factor 2 (Tbr2) was shown to be expressed in a subset of UBCs in mouse cerebellum. Raman spectra show that some defects appear along the edges of the graphene patterns, which were induced by the oxygen plasma-etching treatment of the HOPG surface. Striatal neurons innervating the internal segment of the globus pallidus were heterogeneously distributed predominantly within the matrix but outside the clusters of aggregated striatonigral neurons.

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Cataplexy is considered the most specific symptom of narcolepsy, but its association with anxiety disorders is unknown. Furthermore, the switch to an adult-like progressive distal growth mode during late differentiation stages is reminiscent of the vertebrate progress zone. Cigarette smoking influences cytokine production and antioxidant defences. Short-term persistence at very low concentration was detected in 47 out of 105 women within two days after delivery. typhimurium LT2 sequence at 23 residues, leading to 15 amino-acid differences, but was very close to the S.

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Tumor suppressor gene BRCA-1 is expressed by embryonic and adult neural stem cells and involved in cell proliferation. The dimensions most affected at three months after an acute coronary episode were those related to the physical component.

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In pregnancy, nausea and emesis is most commonly attributed to hyperemesis gravidarum. Treatment of injuries sustained during pregnancy must balance the risks to both the mother and fetus. Although most cases of orofacial clefting and craniosynostosis are isolated and sporadic, these abnormalities are associated with a wide range of genetic syndromes, and making the appropriate diagnosis can guide management and counseling. We also reviewed sonograms of two control groups: 20 consecutive patients with nephrosis unrelated to human immunodeficiency virus (HIV) infection who underwent renal biopsy, and 30 consecutive patients with severe hypoalbuminemia unrelated to kidney disease. The present report reviews data concerning TCR and MS linkage and enumerates the complexities that arise in evaluating results from such studies.

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The purpose of this study was to determine the clinicopathologic predictors of residual disease in patients with high-grade cervical intraepithelial neoplasia (CIN) and margin involvement after initial conization. These results suggest that the haplotype structure in the Japanese population is different from that of other ethnic groups.

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Northern and in situ hybridization analyses of normal and germ cell-deficient testes showed the surprising result that cyclin D1 was expressed in a pattern consistent with expression in the non-dividing Sertoli cells. Here we show that RNS2, an intracellular RNase T2 from Arabidopsis thaliana, is essential for normal ribosomal RNA recycling. Plasma levels of IL-8 and IL-6 were found to be increased and were correlated with measures of insulin resistance in abdominal obese male subjects. IGlu is localized to the dendrites of the bipolar cell, where bipolar cells receive an endogenous glutamatergic input from photoreceptors.

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Mutagenesis analysis and in vitro binding assays provided additional evidence to show that SOX9 affinity is through NF-Y and that SOX9 DNA binding domain is not necessary for SOX9 affinity to those target genes. Moreover, deficiency or therapeutic neutralization of IL-17A did not increase bacterial burden or delay bacterial clearance. novonorm 0 5 mg tabletten um Doctors and the laboratory staff should pay attention to diagnosis of pertussis. Premenopausal osteoporosis, an overlooked consequence of anorexia nervosa.

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The influence of hypothermia on Arthus-phenomenon and leucotaxis. A comparison between kuwait kd india paricel two semi-quantitative bleeding scales for the diagnosis and assessment of bleeding severity in type 1 von Willebrand disease. Blood supply, blood flow and autoregulation in the adenohypophysis, and altered patterns in oestrogen-induced adenomatous hyperplasia. The use of oseltamivir may be a practical intervention to control an H1N1 outbreak an enclosed environment such as this.