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Clirbest (Acyclovir)
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Acyclovir

Clirbest is an antiviral drug that is primarily used for the treatment of HSV (herpes simplex virus) infection as well as infections due to varicella zoster and herpes zoster. It has higher activity towards both HSV-1 and HSV-2 as compared to the latter viral infections. Clirbest remains the drug of choice for prophylaxis and treatment of HSV infection and is available in numerous forms such as tablet, suspension, intravenous injection, and ophthalmic ointment.

Other names for this medication:
Acyclovir, Abduce, Acic, Aciclobeta, Aciclomed, Aciclostad, Aciclovirum, Acifar, Acihexal, Aciklovir, Acitop, Acivir, Acivirex, Acivision, Acix, Actios, Activir, Acycloguanosine, Acyl, Acyrax, Acyvir, Aklovir, Antivir, Asiviral, Avir, Aviral, Avix, Avorax, Blistex, Cicloferon, Cicloviral, Clinovir, Clirbest, Clopes, Clovate, Clovir, Cusiviral, Cyclomed, Cyclovax, Cyclovex, Cyclovir, Danovir, Declovir, Epsin, Eurovir, Hascovir, Hernovir, Herperax, Herpesil, Herpesin, Herpex, Herpin, Herplex, Heviran, Immunovir, Lisovyr, Lovir, Lovire, Lovrak, Medovir, Menova, Ocuvir, Poviral, Ranvir, Remex, Rexan, Scanovir, Sitavig, Sophivir, Soviclor, Supraviran, Telviran, Uniplex, Vilerm, Viraban, Viralex, Viratac, Viratop, Virest, Virestat, Virex, Virless, Viroclear, Virolex, Viromed, Virosil, Virostatic, Virovir, Virucid, Viruderm, Virustat, Virux, Vivorax, Xiclovir, Xorox, Zevin, Ziverone, Zoral, Zorax, Zoraxin, Zovirax,

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Emcor, Theraprim, Tamec, Scanovir, Oxicodal, Precose, Zoloral, Coyenpin, Cicloviral, Zitrocin, Metronide, Cibadrex, Dicloreum, Lamal, Siphene, Jonac, Nortin, Citara, Aciclomed, Ilacox, Atarax, Tromar, Lamotrix, Moxiclav, Elequine, Emimycin, Levox, Zoem, Requip, Afenac, Vivorax, Stopen, Ciprotan, Ceso, Aldozone, Celebrex, Fasarax, Diflex, Neodolpasse, Xanaes, Miorel, Tamoxifen, Globaxol, Claneksi, Sulfamethoxazole, Reslin, Turbovas, Unigastrozol, Inosert, Suganril,

Clirbest belongs to the family of medicines called antivirals. Antivirals are used to treat infections caused by viruses. Usually they work for only one kind or group of virus infections.

Topical Clirbest is used to treat the symptoms of herpes simplex virus infections of the skin, mucous membranes, and genitals (sex organs). Although topical Clirbest will not cure herpes simplex, it may help relieve the pain and discomfort and may help the sores (if any) heal faster. Topical Clirbest may also be used for other conditions as determined by your doctor.

Clirbest is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Ointment
  • Cream

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Nitroreductase activity varied about tenfold among different tumor cells. On the other hand, astrocytes are important in neuronal antioxidant defense and secrete growth factors, which probably provide neuroprotection in the acute phase, as well as promoting neurogenesis and regeneration in the chronic phase after injury. In this report, periodontal treatment of a 42-year-old male patient with generalized severe chronic periodontitis is presented. The effect of ischemic postconditioning, heptanol at different doses (0.03, 0.06, 0.30, and 0.60 mg/kg) and AAP10 (10 mg/kg) on the intact rat heart during 30 min ischemia and 2 h of reperfusion was observed.

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Whole genome amplification methods were used to preamplify isolates to improve the ratio between amplifiable DNA and inhibiting substances. The effect of heavy metal accumulation on metallothionein content in selected tissues of bank voles and yellow-necked mice caught near a steelworks and zinc smelter. A radiomodifying effect of acute hypoxia on neutron-irradiated mice and dogs. Cardiac output, stroke volume, and heart rate were measured using a combination of pulsed Doppler ultrasound and M-mode echocardiography. Both of these proteins are expressed in rat developing coronal sutures.

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Staff as well as users with migration background were underrepresented. Niche partitioning in the coevolution of 2 distinct RNA enzymes. The UV filters in the products with sun protection absorb the UV light emitted by the screens and cause artifacts. Current methods for physical characterization of tissue microenvironments are summarized together with efforts to recapitulate niche mechanics in culture. Wwp2 is present in cartilage where its expression is controlled by Sox9.

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Two hundred and thirty-nine patients with clinical Stage T1 or T2 but surgically node-negative prostate cancer were treated. The patient was not hospitalized, and postoperative patient comfort prevention of the recurrences was achieved. Conferences promote involvement, as they expand and restore relationships, and generate support. Validation of a breast cancer nomogram for predicting nonsentinel lymph node metastases after a positive sentinel node biopsy. LGA status affects the hepatic expression of CYP3A23/1, CYP3A2, and HNF4alpha, suggesting that further research on this issue is warranted.

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Encephalitis is an acute clinical syndrome of the central nervous system (CNS), often associated with fatal outcome or permanent damage, including cognitive and behavioural impairment, affective disorders and epileptic seizures. The possibility that substances applied to the epithelium might reach the central nervous system was investigated by the intranasal application of peroxidase-conjugated wheat germ agglutinin (WGA-HRP).

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During the electron-transfer reactions, the phenolic acids were oxidized to quinoid forms and, in some cases, to polymer products as indicated by comparison of the ultraviolet (UV) spectra obtained in the presence of metmyoglobin/H2O2 with those recorded after oxidation of phenolic acids by horseradish peroxidase/H2O2 and catechol oxidase. A series of 6,7-diphenyl-2,3,8,8a-tetrahydro-1H-indolizin-5-one analogues were synthesized and evaluated for cytotoxic activity against eight human cancer cell lines. Rural community pharmacy: a feasible site for a health promotion and screening service for cardiovascular risk factors. Montmorillonite modified with a quaternary ammonium salt C30B/starch nanocomposite (C30B/ST-NC), silver nanoparticles/starch nanocomposite (Ag-NPs/ST-NC) and both silver nanoparticles/C30B/starch nanocomposites (Ag-NPs/C30B/ST-NC) films were produced.

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Cellular heterogeneity in normal human urothelium: an analysis of optical properties and lectin binding. The International League of Dermatological Societies: from the World Congress of Dermatology to the International Foundation for Dermatology and beyond. This is the first report of a temperature-sensitive dnaA mutant in S.

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Here we show, in aseptic prosthesis loosening, that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. The ALVA-41 cell line was derived from a bony metastasis from a human prostatic carcinoma.

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In contrast, renal stones were less frequent than in developing countries of the world but in the last 20 years investigators began to report high incidences of upper urinary stone disease also from some areas of the Third World concurring with the changing of economic and social conditions. At the bulging stage, the site of primordium initiation shows an intensified expansion that is nearly isotropic.

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Study was conducted of surface structural modification of layered sheets of mica that had been subjected to titanium (Ti) sputter coating, use being made of a variable but mono energetic slow positron beam. The study findings support that risk factors are indeed mode of delivery and parity status specific. Label-free proteomic analysis of PBMCs reveals gender differences in response to long-term antiretroviral therapy of HIV. Expression of c-kit ligand messenger ribonucleic acids in human ovaries and regulation of their steady state levels by gonadotropins in cultured granulosa-luteal cells. Is the employer-based health coverage system a foundation or a relic?

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The functional significance of diabetes-induced apoptosis was studied by treating diabetic mice with a pancaspase inhibitor, z-VAD-fmk (N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone). CCR6 was then shown to promote the recruitment of pro-tumorigenic macrophages to the tumor site, facilitating the onset of neoplasia. Collectively, these studies have implied that the functional limitations imposed by the additional loading of the locomotor system in obesity result in aberrant mechanics and the potential for musculoskeletal injury. Ischemic pre-conditioning enhances the mobilization and recruitment of bone marrow stem cells to protect against ischemia/reperfusion injury in the late phase.

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The automated sample preparation system MixMaster for investigation of volatile organic compounds with mid-infrared evanescent wave spectroscopy. Hierarchical confirmatory factor analyses suggested that at least four of the identified factors are components of an overall mindfulness construct and that the factor structure of mindfulness may vary with meditation experience.

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However, the pattern of thalamic connections to the limbic reticular sector is unknown. Individualized iterative phenotyping for genome-wide analysis of loss-of-function mutations.

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To assess the effects of routinely administered cotrimoxazole on death and illness episodes in children with HIV infection, and in infants of HIV-infected mothers. The aim of our study was to investigate, in primary cultures of human bronchial epithelial cells (HBEC), the effects of TGF-beta (10 ng/ml) on both MAPK activation and apoptosis, in the presence or absence of a pretreatment with budesonide (10-8 M). Visual prognosis after panretinal photocoagulation for proliferative diabetic retinopathy.

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Calcium currents in solitary hair cells isolated from frog crista ampullaris. The combined use of afatinib plus cetuximab emerges as a new possibility for the treatment of patients with advanced NSCLC harboring mutated EGFR after progression on first-generation EGFR TKIs with consequently acquired resistance to TKIs. Search for genes potentially related to germ tube formation in Candida albicans by differential-display reverse transcription polymerase chain reaction. The data also support our previous conclusion that major species differences exist between birds (chicken) and mammals with regard to trophic regulation of presumptive homologous neuronal populations. Human pituitary growth hormone: isolation and properties of two biologically active fragments from plasmin digests.

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Alcohol potently inhibits the kainate receptor-dependent excitatory drive of hippocampal interneurons. Magnesium imide (MgNH) was produced by monitoring the decomposition process of magnesium amide with in situ neutron diffraction. This knowledge may help in the design of strategies to reduce this reabsorption and the resulting nephrotoxicity in peptide receptor radionuclide therapy, enabling more effective therapy. Pneumatic reduction of intussusception in children at the Komfo Anokye Hospital, Kumasi, Ghana.

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The 2 responders who survived at 1 year of follow-up demonstrated an improvement in all 3 parameters examined including an improvement in their follow-up diagnostic imaging results within the first 4 - 6 weeks of STS treatment. The fluid percussion model is in widespread use for the study of brain injury. Uremia in sickle-cell anemia treated by maintenance hemodialysis. Priming of glomerular mesangial cells by activated macrophages causes blunted responses to proinflammatory stimuli. The R3/I5 structure reveals a similar backbone conformation for the relaxin-3 B chain compared to native relaxin-3, and the INSL5 A chain displays a relaxin/insulin-like fold with two parallel helices.

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We report the case of a patient who sustained gunshot wounds to the chest. In the other combination with cyclophosphamide, a synergistic effect was similarly observed but the degree was much higher when cyclophosphamide was administered prior to etoposide administration. Biopsychosocial factors are associated with high prevalence of self-reported musculoskeletal symptoms in the lower extremities among office workers. Toward evidence-based early interventions for acutely traumatized adults and children.

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The Peutz-Jeghers syndrome (PJS) is a hereditary disorder that predisposes an individual to benign and malignant tumors in multiple organ systems. In addition, gender differences in joint coordination were found for both intralimb and interlimb coordination.

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The intracellular mechanism by which L cells sense the organism energy level to coordinate the production of GLP-1 remains unclear. BCSG1-siRNA down-regulates the expression of BCSG1 and inhibits effectively growth of the transplaned human breast cancer cell line in nude mice.

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Activation-associated antigens such as CD11b, CD14 and CD64 of neutrophils have been reported. Estimated blood loss, operative time, and complication rates were compared between primary and revision patients using Student t tests.

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EBV can infect T cells and EBV-positive T lymphomas have been described. These CdR cells synthesized and accumulated markedly elevated levels of metallothionein, a known marker for cadmium resistance, whereas the expression of lysyl oxidase was reduced considerably. After low-dose ACTH challenge, cortisol and dehydroepiandrosterone reached higher levels in patients than in healthy subjects, indicating that the adrenal gland function was not suppressed. To simulate the effects of previous wide cutaneous melanoma excision in sentinel lymph node (SLN) biopsy feasibility through a change in the radiotracer injection site.

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The melanocyte donor site was the arm or forearm where, using an electric vacuum suction machine and a plastic plate, suction blisters were formed. Bevacizumab (0.75 mg/0.03 mL/eye) was injected intravitreally in six eyes of six patients after approval was obtained from the Institutional Review Board of Nagoya University Hospital and an informed consent was signed by the parents.

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Our data indicate that one (or more) compounds with cardiac glycoside-like properties (both immunological and at the receptor level) are present in the plasma of newborns and pregnant women, and confirm the idea that radioimmunological methods may be useful in studying endogenous inhibitors of the sodium pump. Peculiarly, the effects of MAP treatment on both behavior and DA boutons were prevented by combined administration of haloperidol. Prevalence of HIV and Hepatitis B, C, D Infections and Their Associated Risk Factors among Prisoners in Southern Khorasan Province, Iran. UVA tanning devices interact with solar-simulated UV radiation in skin tumor development in hairless mice.

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Family studies and examination of the expressed mutant transporter will be necessary to establish whether this mutation is of functional significance. Plasma AVP increased markedly from its basal (preanesthesia) value in the first group, whereas it did not change in the second group. Numerical modeling of stress in stenotic arteries with microcalcifications: a parameter sensitivity study. Elimination of epidemic methicillin-resistant Staphylococcus aureus from a university hospital and district institutions, Finland.

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Nine consecutive patients with severe sepsis and a documented HLA-DR expression on peripheral monocytes of less than 150 mean fluorescence intensity (MFI) over a period of at least 48 h prior to intervention. Consistently, the PpPRR2 RLD had phosphotransfer ability in vitro, suggesting that PpPRR2 functions as an RR. The views on the patterns of creating the professional flying abilities, their place in the structure of a pilot fitness for flying are discussed. Kinetics of polymer surfactant interactions and the effect of surfactant binding on the conformational dynamics of the polymer were explored in this work using surface plasmon resonance spectroscopy.

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The classification of lymph node metastasis in patients with gastric carcinoma is controversial. Permanent ventricular tachycardia: prognostic and therapeutic problems: three case reports The carotid body plays an important role in the control of ventilation during hypoxia, hypercapnia and acidosis. However, patients do appear to be willing to complete questionnaires and this may be an acceptable format for assessment.

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Our results have identified previously unknown genetic interactions between spt2Delta and mutations in genes encoding transcription elongation factors, including members of the PAF and HIR/HPC complexes. It was concluded that it should be possible to find lines with both the desired resistance genes and good beverage quality. These transcriptional changes are orchestrated with a precision that reminds that of a classical symphony. Myelodysplastic Syndrome with 6q Deletion as the Sole Chromosome Abnormality in an Iranian Patient: A Case Report with Review of Literature. This preliminary analysis supports the inclusion of patients with subclinical axillary disease in trials that randomize to observation alone.

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Vitamin D deficiency may contribute to a pro-inflammatory state in equine perinatal diseases. Our findings suggest a role for IL-7-driven inflammation in atherogenesis and the promotion of clinical instability in coronary artery disease involving interactions between platelets, monocytes, and chemokines. Due to the ability of HIV to switch between CCR(5) and CXCR(4) entry co-receptors, the development of a CXCR(4) antagonist is probably critical to prolonging the effectiveness of HIV therapies in patients. The C terminus of ECM1 interacted specifically with the epidermal growth factor-like modules flanking the LG2 subdomain of perlecan domain V.

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Spatial frequency tuning curves could be predicted from the spatial profiles plotted with bars and edges and the bandwidth could be evaluated more accurately by computing the mean from measured and predicted tuning curves. ApoD also attenuated the increase in oxidative products of arachidonic acid and cholesterol, F(2)-isoprostanes and 7-ketocholesterol, respectively, after kainate treatment.

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In over 1/4 exposed to whole-body vibration disorders of esophagus motility were observed. This protein may be involved in cancer etiology and it may have redox function. Reexamination of the relation between menstrual cycle and kampo diagnosis, yin-yang. Determination of toluene in brain of freely moving mice using solid-phase microextraction technique. These data do not support previous findings of reduced 5-HT1A function in MDD and suggest that hypercortisolaemia or psychotropic medication may have accounted for the attenuation.

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In OSAS patients with bilateral vocal cord paralysis, MLS-associated bilateral posterior cordotomy can be a choice of treatment as an alternative to nCPAP application. Differential diagnosis of mesodermal tumors with myxomatous components Our results demonstrate, for the first time, that the PPP plays a significant role during fungal lipogenesis. The Atlantic cod is an ecologically and economically important North Atlantic fish species and also an emerging aquaculture species. Fast myosin heavy chains expressed in secondary mammalian muscle fibers at the time of their inception.

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