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Casodex (Bicalutamide)

Casodex is a new nonsteroidal antiandrogen developed for use in patients with prostate cancer. The efficacy and tolerability of Casodex as monotherapy and as combination therapy for patients with advanced prostate cancer have been evaluated in randomized clinical trials. Clinical trials are currently in progress to further evaluate Casodex as monotherapy in patients with advanced stages of disease and as adjuvant or first‐line therapy in patients with early‐stage disease.

Other names for this medication:
Bicalutamide, Casodex, Bicalox, Bicalutamida, Bicusan, Bidrostat, Caluran, Calutide, Calutol, Capro, Cosudex, Imda, Lutamidal, Probic, Zolacos,

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Casodex is used together with a luteinizing hormone releasing hormone (LHRH) analog (eg, goserelin or leuprolide) to treat stage D2 metastatic prostate cancer (cancer that has spread) in men. Casodex belongs to the group of medicines called antiandrogens. It works by blocking the effects of testosterone (a male hormone), which helps stop the growth and spread of cancer cells.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet

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It is thought that the L-arginine-NO-polyamine pathway may have a physiological role during pregnancy. However, critical structural information (such as fiber orientation) must be modeled using assumed statistical distributions, with the distribution parameters estimated from fits to the mechanical test data.

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Future modifications to the approach to further improve predictive accuracy are discussed. The results of the present study suggest the usefulness of TBARS measurement as a good biomarker in the estimation of malathion-induced oxidative stress affecting CSF and brain structures. To study these effects in isolation, we established stable mild hypercapnia in female patients breathing spontaneously during sevoflurane anaesthesia, and then gave fentanyl 0.5 microg kg(-1) i.v.

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Levels of volatile sulfur compounds and the analysis of related factors in oral cavities of 384 health subjects in Chengdu Cerebral blood flow affects dose requirements of intracarotid propofol for electrocerebral silence. D-phenylglycine (D-Phg) is an important side chain building block for semi-synthetic penicillins and cephalosporins such as ampicillin and cephalexin. Applied to Drosophila, it is now clear that specific nutrients, not calories, mediate longevity. 2 patients had superficial pin infections that cleared with local therapy and antibiotics, and 1 patient had a reoperation for a nonunion after a fall onto the floor.

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Though the clinical and angiographic results at 1 year showed some impairment as opposed to the 6-months-follow-up, they nevertheless are largely superior to those patients from historic controls not treated with VBT. To this end, we performed the GalNAc enzymatic transfer to two recombinant MUC6 proteins expressed in Escherichia coli, using UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts), which catalyze in vivo the Tn antigen synthesis. Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway.

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Here we examine the synaptic and cellular mechanisms of mGluR-LTD in KO mice and find that mGluR-LTD no longer requires new protein synthesis, in contrast to wild-type (WT) mice. The adverse effects of X-irradiation in the preimplantation period depended upon the day on which the pregnant females were irradiated. Here we use video microscopy to demonstrate both the two-dimensional crystal-like ordering of charged nanometre-sized polystyrene spheres in water, and the enhanced spreading dynamics of a micellar fluid, at the three-phase contact region. Scientific level: Evidence classification proposed by Goodman, describing 10 levels from 1 (high) to 10 (low) and the Agency of Evaluation of Technology (AET) describing 9 levels. About 90 percent of the samples showed no activity of the biocidal substance added, suggesting the uselessness of such substances.

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We used a graphic representation of sequence conservation and base frequency, the sequence logo, to demonstrate that a change in a splice acceptor of hMSH2 (a gene associated with familial nonpolyposis colon cancer) probably does not reduce splicing efficiency. The use of different clinical parameters in the proposed protocol seems crucial to determine the efficacy of ERT, since not all late-onset patients respond similarly to ERT.

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Gallstone ileus -- a relevant differential diagnosis in an aged woman Acute, subacute and chronic toxicity-mutagenicity studies of rifaximin (L/105), a new semisynthetic rifamycin SV antibiotic, were conducted in rats. In the present report, we describe alterations in gene transcription that occur after cannabinoid exposure in a mast cell line, RBL2H3. Nonparticipation of nuclear factor kappa B (NFkappaB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFalpha) induction in lipopolysaccharide (LPS)-stimulated microglia. In this paper we describe the development and testing of an adenovirus-based influenza A virus vaccine directed against the hemagglutinin (HA) protein of the A/Vietnam/1203/2004 (H5N1) (VN/1203/04) strain isolated during the lethal human outbreak in Vietnam from 2003 to 2005.

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Gymnasts also had significantly greater size-adjusted BMC at all sites investigated. Inhibitor of differentiation 2 (Id2) is a natural inhibitor of the basic helix-loop-helix transcription factors. Donor demographics, perioperative and postoperative data, complications, and recipient outcomes have been compiled.

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Microspheres offered better pharmacokinetic and hepatoprotective properties to the drug compared to its solution form. The role of histamine in selective vulnerability of the TH and IC in experimental thiamine-deficient encephalopathy was not supported. Proteolytically generated fragments of caspase-3, -8 and -9 were observed in HeLa cells treated with 60 microM 23-HUA. We undertook this study to evaluate the functional impact of coronary abnormalities in patients with suspected coronary artery disease (CAD) by means of integrated positron emission tomography (PET) and coronary computed tomography angiography (CCTA) scan obtained on a hybrid state-of-the-art PET/CT scanner. Interactions between adenylyl cyclase, CAP and RAS from Saccharomyces cerevisiae.

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Destruction of the raphe nuclei in the midbrain led to a large and comparable decrease in both serotonin content and tryptophan hydroxylase activity of the hippocampus. Comparison of the contents of the main biochemical compounds and the antioxidant activity of some Spanish olive oils as determined by four different radical scavenging tests. We investigated the clinical profile of ICP patients in North India. Coronary heart disease is the most common cause of death in developed countries.

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Two main strategies are possible for controlling their undesirable agonist effects: (1) blocking their biosynthesis by using selective enzyme inhibitors, and (2) antagonizing their hormonal action on a receptor with an antiestrogen or an antiandrogen. Twenty patients with medial knee OA and nine healthy individuals participated in this study.

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No obvious colocalization of CD44 and actin stress fibers was observed before or after treatment with cytochalasin D, and no change in the detergent extraction profile of wild-type and mutant CD44 molecules was effected by cytochalasin D. The main limitations of this study are the small sample of papers and the subjective nature of some of the assessment processes. So far, no single parameter has been developed which is suitable for early prediction of infected pancreatic necrosis. Fibrin and its derivatives in the normal and diseased vessel wall.

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Success of laparoscopic ovarian wedge resection is related to obesity, lipid profile, and insulin levels. A descriptive design was used in which patients attending a weekend cancer support retreat completed the Princess Margaret Hospital Satisfaction with Doctor Questionnaire (PMH-PSQ-MD). In vertebrates these ancestral cell junctions appear to have evolved into more diverse, and possibly more complex, forms, compared with those in their urochordate siblings. The data are registered in cooperation with the Institute of Quality Assurance in Surgery at the Otto-von-Guericke University of Magdeburg (Germany).

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Poor sensitivity of polymerase chain reaction assays of genital skin swabs and urine to detect HPV 6 and 11 DNA in men. Value and utility of disease-specific and generic instruments for assessing disability in patients with migraine, and their relationships with health-related quality of life. Symptoms recurred when specific dietary proteins were reintroduced during open food challenges. The Narcotrend was unable to differentiate reliably between conscious and unconscious patients during general anaesthesia when neuromuscular blocking agents were used. The frequency of anti-HCV increased with the severity of liver histology.

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Aggressive low-density lipoprotein cholesterol lowering in secondary prevention of coronary heart disease. In this study, we linked B1, an anti-cancer peptide, to LHRH and its analogs to improve the activity against cancer cells with LHRH receptor. Thus the effect of different translocation mechanisms on fungal growth and function are identified. These results show that autologous cultured BMSC transplantation is a feasible therapy in clinical-sized bone defects and that such transplants can be assessed noninvasively, suggesting that this technique has potential for use in patients with certain bone defects.

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Finally, as a practical application of antibody-targeted enzymes, the construction and evaluation of an anti-fibrin antibody-single-chain urokinase fusion protein is examined. Molecular docking simulations revealed a huge difference between the mode of interaction of clozapine nitrenium ion and the parent drug.

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Rabbit tracheal epithelial cells were cultured in a serum-free and hormone-supplemented medium with and without retinoic acid. Determinants of responsiveness to 5-fluorouridine in transplantable murine leukemias. Tag SNP selection is an important problem in computational biology and genetics because a small set of tag SNP markers may help reduce the cost of genotyping and thus genome-wide association studies. Increased interleukin-6 activity in cholesteatoma epithelium and stroma correlated significantly with the presence of ossicular and bony erosion and granulation tissue noted intraoperatively. Thirty-seven consecutive patients with an ampullary ectopic pregnancy.

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Conjugation polymer nanobelts: a novel fluorescent sensing platform for nucleic acid detection. The rate of clinically important adverse effects related to ethanol used as an antidote to treat methanol poisoning in children was either absent or low in a tertiary care pediatric hospital setting. Histophysiological study of the cells of human soft tissue myxoma: comparison of data of 14C1 N-acetyl-D-glucosamine, immediate precursor of hyaluronic acid, and of biochemical extraction These injuries are surgical emergencies that demand prompt evaluation and treatment.

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EA can improve the high quality embryo rate, which may be related to its effect in increasing serum and follicular fluid SCF levels. Self-reported adverse events in health care that cause harm: a population-based survey. Effects of three distinct natriuretic peptides on receptor binding and guanylate cyclase activities in rat glioma cells. Apyrase as a novel therapeutic inhibitor of heterotopic ossification.

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A rapid test kit was developed by conjugation of the HIV antigen gp41 and gp36 to 200nm super paramagnetic particles by carbodiimide (EDC) and coating of the HIV antigen gp41 and gp36 to nitrocellulose membrane. Therefore, it is important to consider primary leiomyosarcoma of the pulmonary artery a possibility when a persistent filling defect is present in the pulmonary artery and there is no response to optimal anticoagulation treatment. Correlations between medical and speech language pathology evaluation methods were established, verifying possible statistical signification with the application of Fischer Exact Test. In a model of murine neuronal networks cultured on multi-microelectrode array plates and incubated with plasma from liver failure patients, a normalization of the spike and burst pattern could be observed, if plasma samples from MARS-treated patients before and after treatment were compared. In 10/16 patients, a single IgH rearrangement was amplified from the bone marrow plasma cells.

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This provides a new testbed giving access to static and dynamical properties of the physics of quantum-many-body systems and quantum phase transitions that are hard to simulate on classical computers. Social Cognition and Interaction Training (SCIT) is a manual-based psychological therapy designed to improve social functioning in schizophrenia.

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Here we present the study of the sequence polymorphism in a 1 Mb grapevine genome region at the top of chromosome 18 carrying the fleshless berry mutation (flb) in order, first to identify SNP markers closely linked to the gene and second to search for possible signatures of domestication. We studied the age of the patients to the first consultation according to whether it is received before or after the 6th day of birth, the socio-economic level was appreciated according to the mode of dwelling, accessibility with drinking water and electricity, the diet, associated malformations, the postoperative results. This review covers the very exciting last decade of flavodoxin research, in which the folding pathway, the structure and stability of the apoprotein, the mechanism of FMN recognition, the interactions that stabilize the functional complex and tailor the redox potentials, and many details of the binding and electron transfer to partner proteins have been revealed. No implantations were observed after estrone administration on day 4, but were present when estrone was given on days 5 or 6.

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While muscle contraction is usually triggered by neural signals, which eventually set myosin motors into motion, isolated sarcomeres can oscillate spontaneously between a contracted and a relaxed state. P-selectin glycoprotein ligand-1 is the major counter-receptor for P-selectin on stimulated T cells and is widely distributed in non-functional form on many lymphocytic cells. The ability of Listeria monocytogenes to resist many adverse environmental conditions has been attributed in part to activation of the alternative sigma factor sigma(B), encoded by the sigB gene. The population was composed of 22 patients with vestibular schwannoma in whom both the facial and cochlear nerves could be identified during surgery. Evidence-based care for depression in Maine: dissemination of the Kaiser Permanente Nurse Telecare Program.

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Tuberculous exudative pleurisy in Tbilisi over the last 12 years A model using these values in different CST segments can be used to longitudinally monitor its craniocaudal integrity. Using the pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease.

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Endogenous cannabinoid receptor ligands--anandamide and 2-arachidonoylglycerol Quantitative thermal sensory testing in patients citalopram dose dependent qt interval prolongation symptoms with monomelic amyotrophy. Studies reporting changes in MR after TAVR on an individual level were electronically searched and used for the analysis. These dual roles of arsenic have attracted a renewed research in organ pathophysiology. This system is based on the Scratchpads virtual research environment, the BioVeL portal and the Taverna workflow management tool, which allows for analysis of recordings using a grid computing service.

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Although maternal transcripts deposited in egg cells support several early developmental processes, they appear to be insufficient for zygotic polar growth and subsequent cell divisions. One of these genes, Afu4g14770, designated AfuOSC3, is clustered with genes of cytochrome P450 monooxygenases (P450s), a short-chain dehydrogenase/reductase (SDR), and acyltransferases, which presumably function in triterpene tailoring steps, suggesting that this gene cluster codes for helvolic acid biosynthesis. Performance at age 75 was correlated with self-reported health for measures of processing speed and episodic memory. The herbicide tolerance was further tested by growing the cyanobacterial cultures in BG-11 zurcazol medicine shoppe medium supplemented with varying concentrations of the commonly used rice herbicide, viz butachlor under in vitro condition.

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By providing some nestling clindamycin solution side effects magpies (Pica pica) with methionine, a sulphur amino acid that specifically enhances T-cell immune response in chickens, we investigated this trade-off by directly affecting allocation of limited resources during growth. Vascularized heterotopic autotransplantation of hemispleen in dog.

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