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Carim (Provigil)

Efficacy and safety of modafinil (Carim) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study. This study examined the effect of the novel psychostimulant modafinil (Carim) on a variety of cognitive and behavioral measures including associative learning, sustained attention, inhibitory control, and reaction time.

Other names for this medication:
Provigil, Modafinil, Renea, Modatec, Modapro, Alertec, Modavigil, Modiodal, Modafinilo, Carim, Vigia,

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How Carim works to help increase wakefulness and decrease sleepiness isn’t clear. The drug works in the brain to increase amounts of certain chemical messengers such as dopamine. It also seems to affect the messenger glutamate in certain areas of the brain.

These actions may result in stimulation of brain activities, which could make you feel less tired.

How long does it take to work?

Carim begins to work within 30 to 60 minutes of when you take it. If you take it with food, the drug might take slightly longer to start working.

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We show that a diverse ability of FSHD mesoangioblasts to engraft and differentiate into skeletal muscle of SCID mice is strictly related to the characteristics of the muscle of origin, closely replicating in vivo what was previously observed in vitro. Eight Finnish families, including 46 individuals carrying the risk haplotype, have been typed for four polymorphic microsatellite DNA markers spanning the MEN1 chromosomal region. The application is in the field of adult neurogenesis, neural stem cells and cellular therapy. The results revealed that CDA could activate the complement by way of the classical pathway.

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These findings suggest that exposure to endosulfan during vulnerable periods of neurodevelopment can alter the normal development and potential function of neurotransmission in the frontal cortex. Cerebral energy metabolism in immature and mature guinea pig fetuses during acute asphyxia.

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Eight obstetricians experienced in chorionic villus sampling were asked to estimate the weight of samples of villi with and without a reference photograph. These observations suggest that SCF(Fbw7) ubiquitin ligase regulates phosphorylation-dependent degradation of c-Myb protein. 5-HT innervation of the SCN thus seems unnecessary for the expression and temporal organization of daily torpor. Nightmare disorder with acute onset involves the sudden appearance of frightening and disruptive dreams.

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AMT can be a first-step procedure for ocular surface reconstruction in OCP, but its effectiveness deteriorates slightly over time. Seraspenide, a synthetic tetrapeptide, inhibits cell cycle entry of normal hematopoietic stem cells.

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The cellular form of the prion protein (PrP(c)) is necessary for the development of prion diseases and is a highly conserved protein that may play a role in neuroprotection. As the lesions had gone undiagnosed for many years, this case underscores the need to look for clinical signs of floss-induced damage during periodic examinations. Using dodecylamine, structurally fragile tubular amine containing nanocomposites are obtained, while in the case of the octadecylamine, notoriously stable purely inorganic nanotubes are formed. From this point of view, the dibenzopyrene family are important compounds to be considered.

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Among all hematologic malignancies, B-cell chronic lymphocytic leukemia (BCLL) has the highest familial clustering (three- to sevenfold increase), strongly suggesting a genetic component to its etiology. The sensory symptoms of diabetic polyneuropathy are improved with alpha-lipoic acid: the SYDNEY trial. Time course of mild arm lymphedema after breast conservation treatment for early-stage breast cancer. This information is important to understand why one stem cell would be advantageous over another in cell therapy. Preoperative comorbidity and smoking were risk factors for respiratory complications, whereas neoadjuvant treatment was not.

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To assess the efficacy of a comprehensive program of secondary prevention of cardiovascular disease in general practice. Juvenile hormone binding protein traffic -- Interaction with ATP synthase and lipid transfer proteins. Our previous studies have suggested a chronically low oxygen tension in transplanted pancreatic islets. Poor care may contribute to poor outcomes for treated depression.

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Effects of a few pharmacological agents (ouabain, proserine, atropine) upon absorption velocity in intestinal epithelium, were studied in lower vertebrates. Little is known about the use of Stress Management and Relaxation Techniques (SMART) in racially diverse inpatients. A surgical liver damage and regeneration model in rats was selected using a well-controlled cross tabulated study design. Community-acquired bacterial septic arthritis in adults: diagnosis and treatment

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Discrimination of cerebral ischemic states using bispectrum analysis of EEG and artificial neural network. These results lead to the role of different parameters (microwave power, initial sample mass and diameter of the reactor) on the kinetic and the thermal aspects of the drying. Gross toxicity of bulk Ti-6Al-4V on surrounding tissue could not be found. Other files had no pre-soaking and were then ultrasonically cleaned. Group therapy provides the ideal arena for helping individuals cultivate the observing ego--that part of the sensorium that has the power of witnessing oneself in the world.

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Rapid growth and difficulty of early detection of scirrhous carcinoma of the stomach. High-velocity resistance training for increasing peak muscle power in elderly women.

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Interferon-gamma release assays for the diagnosis of TB pleural effusions: hype or real hope? We are also able to suggest novel methods for experimentally determining reaction fluxes and biochemical affinities at nonequilibrium steady state as well as the overall network connectivity. Isomerization of the valine catabolite isobutyryl-CoA was shown to be only a minor source of this butyryl-CoA. Menstrual cycle-dependent neural plasticity in the adult human brain is hormone, task, and region specific. The aim of this study was to assess splenic volume and to correlate unidimensional measurements with reference volumetric changes in chemotherapy-treated patients with colorectal cancer (CRC) liver metastases.

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Evidence is accumulating for an association between psychosocial stress and elevated blood pressure. This review questions the scientific veracity of this assertion by systematic analysis of published evidences comparing LS versus OS in infants and children.

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The mean values of the Bolton anterior ratio showed neither the sexual dimorphism nor did the mean values of the Bolton total ratio show any differences in sexes. Pertussis is a highly communicable, vaccine-preventable respiratory infection. After day one and throughout the neonatal period BP levels, corrected for birthweight, were higher in the CLD group compared to the non-CLD group, by a mean of 5 mmHg. Further, the results clearly demonstrate the additional benefits on epilepsy, mood and memory brought about by the inclusion of FA in the LTG regimen.

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RasGRP members could be responsible for some of the DAG signaling processes that have previously been attributed to protein kinase C (PKC). Several unrearranged V alpha segments were found to be transcriptionally active in M14T cells.

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The assessment of residual viability with dobutamine stress echocardiography (DSE) in the infarcted area after AMI is relevant to subsequent management and prognosis. Disruption of imprinted gene methylation and expression in cloned preimplantation stage mouse embryos. Indeed, copper treatment rapidly inactivated isopropylmalate dehydratase, an iron-sulfur cluster enzyme in this pathway.

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Country-level stigma was assessed using a combination of national laws and policies affecting sexual minorities and a measure of attitudes held by the citizens of each country. Structures of the two polymers present in the lipopolysaccharide of Burkholderia (Pseudomonas) cepacia serogroup O4.

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Large numbers of acid-fast rods were present in granulomas beginning at 8 wk p.i. We obtained 3357 one-path reads that were then grouped into 1889 independent clusters. These bands arise due to dynamic and/or static coupling of out-of-plane modes with the allowed in-plane modes. A diagnostic work-up including fibreoptic bronchoscopy is indicated early in patients with collapse or mass lesions of the lung. Antibiotics are often given prophylactically, although their role for preventing bacterial meningitis is not established.

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The National Treatment Outcome Research Study (NTORS) is the first prospective national study of treatment outcome among drug misusers in the United Kingdom. Moreover, two separate studies reported that patients with proliferative diabetic retinopathy have increased serum RBP4 levels compared to patients with mild or no retinopathy, yet the effect of increased levels of RBP4 on the retina has not been studied. These observations show that type II collagen is not stringently confined to the chondrocyte but is expressed in skeletal stem/progenitor cells (able to regenerate bone, cartilage, myelosupportive stroma, marrow adipocytes) and in the chondrogenic and osteogenic lineage progeny where collagenolytic activity is a requisite for proper cell and tissue function.

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Evidence is beginning to emerge suggesting that distinct subsets of tumors may exist that reflect distinct categories of immune escape. Here we show that mutations in E7 within the full-length genome which inhibit binding of pRB do not abrogate the ability of the HPV 16 DNA to immortalize primary human epithelial (keratinocyte) cells. Previous studies with UV-induced Fusarium sporotrichioides NRRL 3299 trichothecene mutants defined the Tri1 gene and demonstrated that it was required for addition of the oxygen at the C-8 position during trichothecene biosynthesis.

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This method allows the exact evaluation of the microscopically only insufficiently judgeable cuticle layers. Both alexithymia and depression correlated significantly with most Early Maladaptive Schemas. Glu109 is proposed to play a catalytic role in the decarboxylation reaction. A newborn exposed to drugs in utero can suffer from a varying degree of withdrawal syndrome, a few days after birth. This paper is aimed at analyzing the health-related needs perceived by men and women displaced by the armed conflict and their main strategies to address those needs.

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In 21 conscious unrestrained rabbits, arterial pressure was continuously recorded up to 11 wk by an indwelling catheter placed in the thoracic aorta. We report here the cloning of the entire human gene (LRP1) coding for A2MR/LRP. CuH(3)L and CuH(2)L complexes exhibit the same coordination mode, binding copper(II) through the amino nitrogen atom and a deprotonated alcoholic oxygen atom of the garosamine ring.

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To determine the physiological significance of this increase in C1r and C1s, the amount of IGFBP-5 protease activity that was present in conditioned medium was determined before and after exposure to TNFalpha, IL-beta, and dexamethasone. This new structure shows a typical annexin core structure as we hypothesized, with the D-helix back in place for calcium coordination while parts of the now exposed N-terminal domain are disordered. As a result, these mechanisms have a broad range of selectivity in color space, as do the majority of cells in the early stages of visual processing. Do adult centrioles contain cartwheels and lie at right angles to each other?

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Ataxia-telangiectasia - A historical review and a proposal for a new designation: ATM syndrome. Scanning electron microscopy of contactual interaction of sensitized lymphocytes with homologous target cells. A protein, which neutralizes the enzymatic, toxic, and pharmacological activities of various basic and acidic phospholipases A(2) from the venoms of Bothrops moojeni, Bothrops pirajai, and Bothrops jararacussu, was isolated from B. Women aged 20-49, working as cleaners, seamstresses, nursing, kitchen, or shop assistants in 1980 were followed until 1990 or until receiving disability pension. He was treated with open reduction of the nonunion site, correction of angular deformity, and plate fixation.

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Identification and characterization of foot-and-mouth disease virus O1 Burgwedel/1987 as an intertypic recombinant. In the rat, this is usually accomplished by transection of the carotid sinus and aortic depressor nerves, which is permanent. Unitary potentials from the L5 dorsal root were recorded in response to ramp-and-hold stretches applied at two stretch amplitudes (3 and 4 mm) and four stretch velocities (6, 10, 15, and 30 mm/s) and to sinusoidal stretches applied at four stretch amplitudes (0.12, 0.25, 0.5, and 1 mm) and six stretch frequencies (0.5, 1, 2, 3, 6, and 10 Hz).

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An opto-electronic procedure for the analysis of movement and posture Why professional athletes need a prolonged period of warm-up and other peculiarities of human motor learning. In emulsion-dipped sections, the neurons containing Y1 mRNA transcripts were found particularly in the ventromedial part of the arcuate nucleus. The acute promyelocytic leukemia (APL)-associated fusion protein PML-retinoic acid receptor (RAR) behaves as an aberrant transcriptional repressor, due to its ability to induce chromatin modifications (histone deacetylation and DNA methylation) and silencing of PML-RAR target genes. The cDNA microarray and RNase protection assay using the wild-type and Elongin A-deficient ES cells indicate that the expression of only a small subset of genes is affected in the mutant cells.

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Variating of oxidoreduction potential in skin tubular flaps during acute ischemia Effect of isoproterenol on 85Sr accumulation in the myocardium of the rat during postnatal ontogeny. In addition, the compositional range of enzyme activity is shown to be related to the underlying lipid phase diagram. Recent studies found that distinct MBL2 and FCN2 promoter variants and their corresponding serum levels are associated with relative protection from urogenital schistosomiasis. We prospectively examined the impact of an initial interdisciplinary genetic counseling (human geneticist, oncologist, and psycho-oncologist) on feelings of anxiety with a special focus on subgroups related to personal cancer history, gender, age, and education.

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Anti-inflammatory effects of statins are considered to be exerted in part through inhibition of leukocyte-endothelial interactions. Texting while driving had the greatest negative impact on driving performance, particularly with regard to variability in lane position (i.e., RMS). Textbooks were written by all local pharmacy teachers of the university, some of them (those by Grindel, Giese, Goebel, Dragendorff) were also translated into other languages and used at several universities. Transgenic mice that contain a proline to leucine mutation at amino acid 101 in the endogenous murine PrP gene have been produced by gene targeting.

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Experimental complex partial seizures induced by a microinjection of kainic acid into limbic structures. Boari operations and ureterocystoneostomies were fulfilled in 72 puppies. During dental treatment patients may also be confronted with situations that give rise to extreme fear of suffocating or being choked (mouth full of water, the making of dental radiographs and dental impressions).

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The assay detected 1-10 genome copies per test tube and was specific in showing no positive results when samples containing human or bovine adenoviruses were analyzed. Parents completed self-report assessments of mental health service use and barriers, prolonged grief, depression, anxiety, attachment styles, and sense of meaning by phone, in person, or on their own. However, when injected into the nucleus accumbens, NN was markedly less potent than NT at inhibiting DA-induced behavioral hyperactivity.

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Finally, maternal ethanol consumption significantly increased relative placenta weights as well as placental DNA and protein content. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Cadmium induced changes in subcellular glutathione contents within glandular trichomes of Cucurbita pepo L. Although hydrofluoric (HF) acid burns may cause extensive tissue damage, severe systemic toxicity is not common after mild dermal exposure. To assess the usefulness of aspiration sclerotherapy in the treatment of hydroceles in the tropics.

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Screening for cystic fibrosis mutations in southern France: identification of a frameshift mutation and two missense variations. However, the combination of CPZ and EMB did not result in augmented antimycobacterial activity. Appearance of SBA, PNA, and VV lectin binding carbohydrates in the alpha 1,3GT gene-transfected melanoma cells is a result of reduction of cell membrane sialylation and unmasking of these carbohydrates. Two concurrent randomized controlled trials with 24-month follow-up.

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Basal PKC activities and immunoreactivities of PKC-alpha and -zeta were higher in multidrug-resistant cells than in multidrug-sensitive cells. The growth of leukemic blast progenitors is supported by growth factors and colony-stimulating factors (CSFs) have been shown to stimulate this phenomenon in vitro. At 9 days postoperatively, grafts were no longer at risk of being dislodged.

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The trans-encoded antisense RNAs are small RNAs which display only partial complementarity to their target RNAs. Nitric oxide-mediated increase in tumor blood flow and oxygenation of tumors implanted in muscles stimulated by electric pulses. The segmental osteotomy in the management of malposed implants: a case report and literature review. This demonstrates that plastids can be discharged from the pollen tube into the egg with little or no concomitant transmission of paternal nuclear genes. Estimates of the signal-to-noise ratio were obtained using typical parameters of piezoelectric transducers and optical properties of tissue.

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Information was gathered using a questionnaire which was sent to 312 men who had previously attended our laboratory for semen analysis. Intravenous administration of 10 micrograms of estrogen and measurement of monoamines 1 h later was not associated with altered levels of any monoamine suggesting that the estrogen-dependent changes are consistent with the genomic model for steroid hormone action.(ABSTRACT TRUNCATED AT 250 WORDS) Conservative surgical treatment for cervical cancer may increase the risk of late fetal loss or preterm birth. However, infectivity in vivo was not blocked completely as long as the capacity of ORF47 protein to bind IE62 protein was preserved, a function that we identified and mapped to the N-terminal domain of ORF47 protein.

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By analysis of the motion of charged and uncharged probes in one membrane one can distinguish between the motion caused by the electric field acting on the charge of individual probes and that caused by frictional forces due to electroosmosis. The manipulation of domains by external fields in ferroic materials is of major interest for applications. Endometriosis is characterized by the presence of endometrial cells with capacity to avoid apoptosis outside the uterus. In recent years, rotary instruments and techniques have gained importance because of the great efficacy, speed and safety of the preparation procedure. Electron microscopic and gradient analyses revealed that the mutant virus did not assemble any viral particles in 293 cells.

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Part of the inhibitory signal in the FVIII cDNA has been localized to a 1.2-kb inhibitory sequence (FVIII INS), which decreased steady-state RNA levels from a retroviral vector by 30- to 100-fold. Without the silane agent, hydrofluoric acid-etched specimens had a higher bond strength than polished or phosphoric acid-etched specimens. Making up for lost time: the experience of separation and reunification among immigrant families. Abstracts of the 12th Asian Congress of Urology of the Urological Association of Asia, December 5-9, 2014, Kish Island, Iran. In this study the heritability of fasting plasma glucose (FPG) was estimated in participants in the Erasmus Rucphen Family study, who were members of a single pedigree from a young genetic isolate.

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The K179M form of Akt/PKB abolished palmitate-induced cell proliferation at the low dose and death at the high dose. The cytopathic effect was not dependent on the release of free radicals. We also tested whether inhibition of nuclear factor kappa-B (NF-kappaB) and activator protein-1 (AP-1) by curcumin is involved in these mechanisms.

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The mean age at the time of the latest assessment (for the 51 survivors with adequate follow-up) was 31 months. Both zyxin and Twist1 were predominantly expressed in the cardiac atrioventricular canal (AVC) that undergoes EMT during heart development. CrFK cells were transfected with DNA of these chimeric clones and co-cultivated with thymocytes.

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The concentrations of glutamate, aspartate, glycine, GABA and serine were determined in the cerebral cortex, the brain stem and the cerebellum. Tests were conducted to probe for a derived transfer of mand response functions from A1 and A2 to C1 and C2, respectively. Real-time PCR with melting curve analysis of PCR products is a rapid procedure for detecting and genotyping herpes simplex virus (HSV). Because of the analysis of a unique Twitter dataset captured vancomycin trough test tube color for dilantin in the early stage of the current Ebola outbreak, our results provide insight into the intersection of social media and public health outbreak surveillance. Significant elevation of the level of medium-mass molecules was noted in patients with pyo-inflammatory complications.

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Transcription factor AP-2 diclofenac pediatric dose regulates human insulin-like growth factor binding protein-5 gene expression. However, we observed nominal significant associations of 2 SNPs in the NDUFS1 gene and 4 SNPs in the NDUFS2 gene with early onset schizophrenia (EOS), but none of these associations survived the Bonferroni correction.

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WR279,396, a third generation aminoglycoside ointment for the treatment of Leishmania major cutaneous leishmaniasis: a phase 2, randomized, double blind, placebo controlled study. Kinetics and persistence of neutralizing antibodies against bovine viral diarrhea virus-1 and -2 and border disease virus after two step vaccination of cattle Since 1990, the incidence of conjunctival neoplasia has more than tripled in Uganda. Between March 1991 and October 1993, 49 patients with inoperable head and neck carcinoma were randomly assigned to receive either radiation therapy alone (group A) or radiotherapy combined with simultaneous application combutol medicine of Mitomycin C and Bleomycin (group B). This study was undertaken to identify the spectrum of clinical manifestations based on self-report from affected patients.

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