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The two shortest-acting compounds, A-4166 and KAD-1229, will be developed to be taken prior to each main meal, while the slower, longer duration agents, Repaglinide and BTS 67 582, may be developed to be taken twice daily. Blood concentrations of Repaglinide were proportional to the dose administered.

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Repaglinide is used together with diet and exercise to treat high blood sugar (glucose) levels in patients with type 2 diabetes. Repaglinide works by causing your pancreas to release more insulin into the blood stream. This medicine does not help patients who have insulin-dependent or type 1 diabetes.

This medicine is available only with your doctor's prescription.

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pneumoniae detection contributes to atherosclerosis, the association between immunohistochemical detection of C. Clodronic acid formulations available in Europe and their use in osteoporosis: a review. The craniocervical region is commonly affected by a number of pathologic processes. Antisense oligonucleotides: design, construction, and applications to cardiac allograft transfer. Furthermore we demonstrated that YPEL3 is growth suppressive, triggering cellular senescence in human cell lines and is down-regulated in several human tumors.

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Moreover, COX-2 may participate in polyp enlargement through angiogenesis by promoting VEGF production. Generally, the immunoreactive fibres, nerve networks or bundles were distributed under the serous membrane, among smooth muscle of muscular membranes, in the submucosal layer and under the luminar epithelium of the uterine cervix and vagina. A 12-day course of low dose of rifabutin with an increased dose of amoxicillin and pantoprazole is well-tolerated and highly effective against dual-resistant H. Although no variables were found which met all of the criteria necessary to be considered a determinant of the gait transition, there were variables which distinguished between a HS and FF strike landing pattern as obstacle height increased. The administration was given by oral gavage once daily for 2 weeks.

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Dendritic cells (DCs) are important both in amplifying the innate immune response and in initiating adaptive immunity and shaping the type of T helper (Th) response. Coupling losses of rectangular waveguide resonators are discussed in this paper in terms of fourier analysis theorem.

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We found that CHD deaths fluctuated with daily stock changes in Shanghai, suggesting that stock volatility may adversely affect cardiovascular health. It most commonly affects the lungs, but rare oral manifestations of TB have been reported. Rats were exposed to a brief, variable childhood or prepubertal stress protocol (Postnatal Days 25-27), and their behavior in a delay discounting task was compared with that of control animals in adulthood.

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The disease is caused by mutation in genes encoding proteins required for the Fanconi anemia pathway, a response mechanism to replicative stress, including that caused by genotoxins that cause DNA interstrand crosslinks. Care for the elderly now available from visiting nurse service agencies

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The values of the intraclass correlation coefficients were mostly around 0.5 and showed significant within-pair similarity of test scores. In Prolonged group, patients underwent extra oral capecitabine 1000mg/m(2) twice daily on days 1-14 of a 3-week cycle for eight cycles after eight cycles of XELOX. We have also demonstrated that the adhesion of tumor cells to IL-1 beta-treated human umbilical vein endothelial cells can be inhibited by anti-NF kappa B reagents such as N-acetyl L-cysteine, aspirin, or pentoxifylline. Patient non-compliance with prescribed treatment is an important factor in the lack of success in cardiovascular prevention.

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Biochemical changes in atherosclerosis: current concepts and experimental applications To prob the effect of lactic acid on the survival rate of cultured rat cortex neurons. There was no difference between DNA methylation level between normal endometrium and hyperplastic changes. Diagnostic possibilities in professional gastroenterologic practice

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Many potentially relevant signals are generated after injury, and the nature of this mechanism has not been elucidated for any instance of regeneration. An outpatient clinic-oriented laboratory system--proposal for a personal computer network system DSC and FT-IR studies suggested that an electrostatic interaction between CS and Carbopol contributes at least in part to the stabilization of pilocarpine/CS/Carbopol nanoparticles. This treatment can be combined with more classical chemotherapy (5-fluorouracil, streptozotocine). Retinoids have an important role in cell growth, morphogenesis and differentiation.

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At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. Downregulation of MDC1 expression by small interfering RNA yields a radio-resistant DNA synthesis (RDS) phenotype and prevents ionizing radiation-induced focus formation by the MRE11 complex. Hemolysis was severe, and ceased promptly when the drug was discontinued. This study explored the incidence and aetiology of bloodstream infections after patients received the pneumococcal conjugate vaccination and a risk-based intrapartum antibiotic prophylaxis against early onset sepsis caused by group B streptococcus.

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They all answered a structured interview by their physicians to determine the IBS subtype and to evaluate their symptoms intensity (Likert Scales). Aside from its clinical presentation, the severity of this form of the disease is due to the difficulties in diagnosis and treatment. Except for gastrointestinal side effects, itraconazole is well tolerated.

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Moreover, we compared the immunostimulatory properties of plasmids that were modified by the addition of two to four CpG motifs. A chemogenomic approach to drug discovery: focus on cardiovascular diseases. Rehabilitation of a severe, case of acne conglobata through close dermatologic-surgical cooperation

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Our data point to pleiotropic regulatory role of adpA19(at), warranting its use as a tool to manipulate secondary metabolome of actinomycetes. It implies that more Tibetan medicinal plants and traditional knowledge can be discovered. A 25-year-old multigravida drank an organochlorine insecticide in an attempt to commit suicide at 16 weeks of pregnancy. elegans fat-3 mutants lack Delta6 desaturase activity and fail to produce C20 PUFAs. Is hepato-imino diacetic acid scan a better imaging modality than abdominal ultrasound for diagnosing acute cholecystitis?

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Important modern prognostic markers such as heart rate recovery (HRR), chronotropic index, delayed systolic blood pressure (SBP) response and Duke treadmill score (DTS) have been evaluated by treadmill exercise testing. Small, nondisrupted pieces of human nasal polyp tissues were subcutaneously implanted into SCID mice depleted of natural killer cells.

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Therefore special attention is payed to this group of patients in this study. LctM demonstrates highly processive behavior as seen by MS analysis of the reaction course of dehydration. Targeted antiprotease delivery paralleled hpIgR expression in the respiratory epithelium in vivo and was not increased by escalating dose, so airway penetration was receptor-dependent, not dose-dependent. These struts can be made from hemicylinders of diaphyseal bone or from fibulae.

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Nodular parenchymal and, less frequently, tracheobronchial amyloidosis had contiguous cellular infiltrates of plasma cells, lymphocytes, and giant cells. Neonates of HbSS mothers had a statistically lower than normal mean birth weight and gestational age, but only a shorter mean gestation significantly distinguished those of the HbSC and HbAA mothers. To a limited extent, the presence of high-binding alleles at the FcgRIIIA locus or at the FcgRIIIA-FcgRIIA haplotype might predispose to RA in SE positive individuals. Cognitive deficits are a characteristic feature of schizophrenia and contribute to the profound disabilities associated with this illness. Thus, Bca1 is a novel assembly factor for the respiratory complex III.

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Familial congenital occipitoatlantoaxial malformation (OAAM) in the Arabian horse. To review the literature published during the past year relevant to identifying the best measures for monitoring progress in the treatment of child and adolescent clients and their families. AVP shares some important properties with these hormones and is activated in HF. Careful analysis of the post-EMR specimen and resection defect may reveal a target sign, an easily recognized and reliable marker of either partial- or full-thickness MP resection and potential perforation. Scientific and practical achievements in controlling tuberculosis in the Tadzhik SSR

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We suggest that urban attack rates in the 1918-1919 pandemic were constrained by prior immunity, that R(0) for influenza is higher than often assumed, and that control of any future pandemic could be difficult in the absence of significant prior immunity. A descriptive, retrospective study, from January 1993 to March 1994.

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Mnemogenic effects of injecting RA-octil, a CE-inhibitor derivate, systemically or into the basal forebrain. Occurrence of Gonadoblastoma in Patients with 45,X/46,XY Mosaicism. The self-association activity resides, in part, in the N-terminal region of 170 residues, which also constitutes the dsRNA-binding domain (DRBD). (1) the contents of p-tyr-pr in all three fractions (P2, P3, S3) decreased 15 min after ischemia, but the contents of p-tyr-pr in S3 fraction decreased more obviously than the others did, With the increase of reperfusion time, the contents of p-tyr-pr in all of these fractions recovered gradually, but the p-tyr-pr in S3 fraction increased more rapidly among them, in the P2 fraction, the contents of p-tyr-pr increased slowly, but significantly and sustained longer during reperfusion when compared with that of P3 did. With this procedure, surgeons can inspect hidden structures, dissect perforators at the back of the aneurysm, identify important vessel segments without retraction of the aneurysm or arteries, and check for completion of clipping.

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Malassezia yeasts are associated with a number of dermatologic and systemic diseases in humans and animals. The effect of CRMP4 on chromosomal alignment is dependent on phosphorylation by GSK3 identifying CRMP4 as a critical GSK3 substrate during mitotic progression. Migration of flMSCs induced by SDF-1alpha in vitro was detected by Boyden chamber assay.

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Fetuin is a substrate for Pasteurella haemolytica O-sialoglycoprotease. B cell-deficient mice could prime a type II collagen-reactive T cell response, thus excluding B cells as obligatory antigen-presenting cells for the priming of collagen-reactive T cells. This semiautomatic algorithm will allow for repeatable, efficient, and masked ciliary muscle measurements in large datasets. This method of phasing diffuse scattering may have application to scattering from individual inorganic nanostructures or single macromolecules.

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Synthesis of optically pure 4-fluoro-glutamines as potential metabolic imaging agents for tumors. Here, we describe the spatio-temporal expression patterns of both genes during mouse embryogenesis.

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Following an incubation phase, monocytes were isolated by adherence to glass tissue culture slides. Our results provide structural and mechanistic insights into several important proteins functioning in bacterial pathogenesis. We confirm previous knowledge, describe new molecules, and we have built up a model for human in vitro decidualization as invaluable tool for the diagnosis, therapy, and interpretation of biological phenomena. We tested the hypothesis that differences in the expression of certain molecular markers of colon cancer may account for different clinical outcomes. One month after surgery the incisors were dissected and the tissues were prepared for light microscopy and morphometric measurements.

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For all these substrates, Doa10 requires two Ub-conjugating enzymes, Ubc6 and Ubc7, as well as the Ubc7 cofactor Cue1. The photoinduced formation of gold nanoparticles in a mesoporous titania gel monolith. How they grow up: 41 physically handicapped children and their families. Such a random behavior of single electrons is used for high-quality random-number generation suitable for data processing which stochastically extracts the most preferable pattern among various ones.

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A new multifunctional compliant instrument has been designed for use in minimally invasive surgery. In this paper we extend our previous work on blood flow in a simple two node network and begin to explore how topological complexity influences the dynamics of network blood flow. Outpatient parenteral antibiotic therapy in the elderly: an Italian observational multicenter study.

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While the SiO2/TiO2-Pt nanostructure displayed a similar photocatalytic activity to that of Degussa P25, the former can be easily separated from the reaction medium by sedimentation. Peroxisome proliferator-activated receptor gamma inhibits the migration of dendritic cells: consequences for the immune response.

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Short-term effect of caffeine on purine, pyrimidine and pyridine metabolism in rice (Oryza sativa) seedlings. Comparison of laser-Doppler vibrometry results and audiometry may be a sensitive and selective indicator of ossicular pathologic conditions as well as a useful tool for investigating middle ear function.

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Pericardial rupture and cardiac herniation after blunt chest trauma. Stress fractures of the proximal phalanx of the great toe: a report of four cases. Activity of the oxazolidinones AZD2563 and linezolid against Corynebacterium jeikeium and other Corynebacterium spp. Since 1981 when anti-Ro (SS-A) and/or anti-La (SS-B) antibodies were described to be present in infants with neonatal lupus erythematosus (NLE) and their mothers, subsequent studies have demonstrated the almost universal association of NLE with either or both of these autoantibodies.

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Chondroblastoma occurs most frequently in the proximal part of the tibia and the proximal part of the femur with significant male predilection. Campylobacter bacteremia, cholecystitis, and the acquired immunodeficiency syndrome. This assay facilitates detection of immune responses over time, as well as distinctions in antigens recognized by host T cells. We discuss the effects that a secular trend in incidence would have on estimation of familial relative risk (ratio of observed to expected cumulative incidence among relatives of index cases). The reduction rate of methylene blue increased by more than 150 times in the SiO2/TiO2 modified micro-space compared to that in a batch system.

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The CD1d natural killer T-cell antigen presentation pathway is highly conserved between humans and rhesus macaques. Stem-cell research is being investigated for the treatment of retina diseases. Levels of blood or colostral lymphocyte transformation responses at delivery were unaffected by exposure to RS virus in pregnancy. Localization and distribution of desmin and vimentin have been studied in different neuromuscular disorders using monoclonal antibodies. Synthetic function of airway smooth muscle (ASM), defined as secretion of cytokines or chemokines, may regulate airway inflammatory responses in chronic obstructive lung diseases.

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Using primers designed on the basis of sequence homologies in the copper-binding domains for a number of plant and fungal tyrosinases, two tyrosinase encoding cDNAs were cloned from an Agaricus bisporus U1 cDNA-library. Time course of the in vivo effects of thyroid hormone on cardiac gene expression.

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Joint effects of cigarette smoking and irradiation in pregnant mice and their offspring. Immunohistochemical investigations for the detection of lymphocyte subsets in the human oviduct have been performed.

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Hemi-orolingual angioedema and ACE inhibition after alteplase treatment of stroke. Screening of our corporate compound collection with an assay measuring the cooperative binding of E1 and E2 to the origin identified a class of small molecule inhibitors of the protein interaction between E1 and E2. D-serine is considered to be a permissive factor for long-term changes in synaptic plasticity and neuronal migration through activation of NMDA receptors. Review: multivitamins and mineral supplements do not reduce infections in elderly people.

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Several 3-keto-synthases have been studied, including the soluble fatty acid synthases, those involved in polyketide synthesis, and the FAE1-like 3-ketoacyl-CoA synthases. Five cytokines, tumor necrosis factor-alpha, transforming growth factor-beta 1 and 2, and interleukin-1 and 6, were immunolocalized in human cholesteatoma epithelium and subepithelial stroma, with greater intensity of staining compared with noninflamed external auditory canal skin. Fungal peritonitis (FP) is a serious complication for peritoneal dialysis (PD) patients, determining hospitalization, technique failure, catheter loss and death. Knowledge of the management of tooth fracture and storage medium differs between previous casualties and non-casualties. Antimicrobial susceptibilities of canine Clostridium difficile and Clostridium perfringens isolates to commonly utilized antimicrobial drugs.

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The patient had an impacted upper left second premolar because of an odontogenic keratocyst and showed a skeletal Class II jaw base relationship. Based on recent research it became clear that it is secreted not only by the kidney, but by the central nervous system as well, and erythropoietin receptors are present there, too. Inhibition of NEP-enzyme activity may effectively improve the relaxing capacity of epicardial coronary arteries under hypoxic/hyperkalemic conditions. Making agreements on how to behave has been shown to be an evolutionarily viable strategy in one-shot social dilemmas. This study investigates associations between social skills (aggression and prosocial behavior) and literacy achievement in a sample of low-income children (between 4 and 6 years old when the study began) during elementary school.

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We believe that the paraneoplastic effect of myxoma on the FVII activity levels is previously unreported. This was an open prospective study with a limited number of patients who were concomitantly treated with calcipotriol and salicylic acid ointment. Sex, ecology and the brain: evolutionary correlates of brain structure volumes in Tanganyikan cichlids.

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These findings may lead to a better understanding of the role of diet in gastrointestinal maturation and may constitute a basis for the treatment of mammals having an immature gut. There is no strong evidence supporting the use of preoperative intra-aortic balloon pump (IABP) in high-risk patients undergoing coronary artery bypass grafting (CABG). Foscarnet resistance is thus likely to be mediated through an altered interaction of the mutant enzyme with the template strand of the template primer which distorts the geometry of the polymerase active site and thereby decreases foscarnet binding. We describe an imaging system that provides high-resolution images through an annular aperture using the unwanted kinzalmono 40 mg nebenwirkungen hormonspirale low spatial frequency light for image stabilization.

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Constitutive expression of a peanut ubiquitin-conjugating enzyme gene in Arabidopsis confers improved water-stress tolerance through regulation of stress-responsive gene expression. The high initial Ni availability of fluzole for yeast infection soil Serp (470.5 mg kg(-1)) was the main explanation for the high Ni concentrations measured in plant shoots grown on this soil, compared to those grown on soils Calc and Silt A. Intracardiac thrombosis occurs frequently in cardiac amyloid patients, especially in the AL type and in those with atrial fibrillation. Increased venous admixture is due to a regional decrease in the ventilation/perfusion ratio which is largely dependent on pulmonary hemodynamic disorders.

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Illness behavior in patients on long-term sick leave due to chronic musculoskeletal pain. However, the most abundant RAPD group was composed of 35 strains, which could lead to the conclusion that they share a common origin and were distributed by the movement of infected grapevine cabgolin tablet use as phone planting material as a most common way of crossing long distances. Group I was treated for 3, group II for 7 and group III for 17 consecutive days. Studies were conducted in an experimental in vitro BBB model comprising bovine brain capillary endothelial cells (BCECs) and rat astrocytes (RAs). Morbidity and mortality are less important compared with other techniques.

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This downregulation of MRP2 contributes to increase in paclitaxel-induced G2/M arrest and apoptosis, which might be due to intracellular accumulation of paclitaxel. We recommend regular training workshops and seminars for this purpose. A multivariate regression analysis identified GCS, occlusive hydrocephalus, mechanical ventilation, and systemic sepsis as independent risk factors for PEG tube placement. Haemoglobin was incubated in lamotrigine and depression bipolar air-equilibrated citrate buffers between pH 5 and 7 and the percentage decrease in oxygen saturation relative to pH 8 determined by spectral deconvolution. The method was applied to bile and urine samples collected in rats, after a single high oral dose of 100 mg/kg of tropatepine hydrochloride.

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Large administrative database containing health care information for 587,010 people living in 1 state who were enrolled in the Medicare or Medicaid programs. The occurrence of psammoma bodies zithrox tablets sale in papillary adenocarcinoma of the lung. Finally, either inhibition or disruption of p38MAPK increased peroxisome proliferator-activated receptor (PPAR)gamma expression and transactivation. In adenovirus type 12 transformed cells, the down-regulation of MHC class I transcription contributes to the tumorigenic phenotype and is solely mediated by Ad12 E1A. Lung inflammation biomarkers and lung function in children chronically exposed to arsenic.

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Animals were monitored for donor-specific hyporesponsiveness by MLR and alloantibody determination. An in vitro screening cascade to identify neuroprotective antioxidants in ALS. Hypodontia of primary and permanent dentition is one of the cymbalta 60mg hard gastro-resistant capsules duloxetine cymbalta most frequently occurring oral symptoms in HED patients. Cardiac resynchronization therapy has revolutionized the management of systolic heart failure in patients with prolonged QRS during the past 20 years. Films presented antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans without significant differences between Ag-NPs concentrations.

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Plasma samples statistically significantly inhibited matrix metalloproteinase 9 (MMP-9) release from human monocytes and NF-kappaB activation. Spinal immobilisaton in pre-hospital and emergency care: A systematic review of the literature. orlistat 120mg boots on sale Based on its infectious clone (pBR-XJ-160) we have developed an RNA-based vector system. The fungus shows considerable variation for pathogenicity in nature. Institutions may need to increase coordination between multidisciplinary clinical teams to optimize patient care.

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Six macaques were taught task switching (TS) and delayed alternation (DA) paradigms. Dietary factors that affect bioavailability of zinc in ruminants are not well defined. In addition, the GJE extract and neobrufen 600 mg abbott ursolic acid had cytotoxic activity against AGS and SUN638 gastric cancer cells. Comparison of solution structures of mutant bovine pancreatic trypsin inhibitor proteins using two-dimensional nuclear magnetic resonance.

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Guideline-conformity of initiation with oral hypoglycemic treatment for patients with newly therapy-dependent type 2 diabetes mellitus in Austria. Resistance sintering under ultra high pressure: a new approach to produce bulk nanocrystalline refractory metal. The site of interaction of a SAT molecule was investigated by gel chromatography and surface plasmon technique using various mutant-type SATs, to better understand the mechanism involved in complex formation. Imatinib plus peginterferon alfa-2a in chronic myeloid leukemia. The training increased PHC workers knowledge overal l tablet about the concept, recognition and management of depression.