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Cyclophosphamide belongs to a class of drugs called alkylating agents. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. Cyclophosphamide works by stopping or slowing the growth or spread of certain cancer cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Cyclophosphamide injection is also sometimes used to treat a certain type of lung cancer (small cell lung cancer; SCLC). It is also used to treat rhabdomyosarcoma (a type of cancer of the muscles) and Ewing's sarcoma (a type of bone cancer) in children. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

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The lack of capillaries in the middle region suggests that the preexisting capillaries adjacent to the implantation site underwent enlargement and/or fusion and recruited a smooth muscle coat. These results indicate that activated, membrane-bound cytidylyltransferase is associated with the nuclear membrane and suggest that the nuclear membrane may be a site of de novo phosphatidylcholine synthesis.

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At this moment, primarily immunosuppressive and cytostatic substances are used as active coatings. Their possible differential use with regard to the different epileptic syndromes and to the specific epileptologic history of the patient are examined. Navigation liver surgery for complex hydatid cyst with biliary tree communication. The reason for the observed lower level of CMV IgG in BS is not clear.

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Stimulation of the human promonocytic cell line U937 with antibody-coated chicken red blood cells (Ab-CRBC), leads to inositol phosphate (IP) release in the effector cells. Postoperative prophylactic TACE may be able to suppress the recurrence formation for HCC patients with or without definite residual lesion within 6 months. GLP-1 receptor expression in rat major salivary glands and the effects of bilateral maxillary molar extraction on its expression Our methodology represents a paradigm shift in the use of NMR active tags in structure determination of small molecules in complex mixtures.

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However, either type of transfectants brought about the marked reduction in the accumulation of triacylglycerols after the standard adipogenesis program. The clinical safety of long-term lansoprazole therapy for the maintenance of healed erosive oesophagitis has not been extensively studied in clinical trials. The positive clones suitable for discrimination sibling species of An. Popular preparations include expressed juice from the aerial parts of the plant (which contain polysaccharides) and alcoholic tinctures from roots (containing caffeic acid derivatives and alkylamides). Analyses of deciduous tooth enamel in an individual with a homozygous WDR72 mutation identified changes consistent with a late failure of enamel maturation without retention of matrix proteins.

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One is QuantiFERON TB-2G (QFT-2G, called Quanti FERON-TB Gold outside Japan), which uses the whole blood and has been approved as a diagnostic test for tuberculosis infection in Japan. Forskolin increased intracellular cyclic AMP levels and inhibited epidermal growth factor stimulated thymidine incorporation in an equivalent manner in both SHR and WKY adventitial fibroblasts, implying that there is no difference in adenylylcyclase activity.

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Endotoxic shock follows a cascade of events initiated by release of lipopolysaccharide during infection with Gram-negative organisms. Confounders are often not measured in the epidemiologic databases. The KIV model approximates the operation of the basic vertebrate forebrain together with the basal ganglia and motor systems. Intervention effects of supplying homeless individuals with permanent housing: a 3-year prospective study.

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It was suggested that Zn selected populations with increased resistance prevalence to sulfamethoxazole or ciprofloxacin. The history of recurrent cough with fetid sputum, hemoptysis, or recurrent pneumonia were the most important clues to early diagnosis of this disease. The results of the MP/DHPLC or the MP/capillary electrophoresis assay were all confirmed by PCR-restriction fragment length polymorphism analysis. EDTA induces rapid fibrillation of sCT in water and the partially reversible formation of a noncovalent, insoluble sCT/EDTA precipitate.

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Antiarrhythmic drug therapy of atrial fibrillation: focus on new agents. Operating at high-pH provides excellent peak shapes and retention, and accentuates selectivity differences of structurally similar impurities and degradants.

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Application of microbore HPLC in combination with tandem MS for the quantification of rosuvastatin in human plasma. In this study, we utilized a proteomic approach involving two-dimensional differential gel electrophoresis, mass spectrometry, and function-based activity profiling to examine changes in the gut proteins from the larvae of an Indianmeal moth (IMM, Plodia interpunctella) colony exhibiting resistance to Bt. Apparatus for measuring the swelling dependent electrical conductivity of charged hydrated soft tissues. After HS their courtship intensity does not decrease and the main parameters of their courtship behavior and communicative sound signals in comparison tu wild type males either do not change, or appear to be even better stabilized. An electron dense layer was observed on some cells in the presence of ruthenium red stain and cells possessing this layer were phagocytosed in vivo.

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In addition to a descriptive statistical analysis a subgroup classification of fatherhood-variables associated with other independent variables, i. We report on a series of 6 patients from 2 tertiary pediatric hospitals that had intravascular segments of long-term central venous lines that could not be removed and so were left in situ. Calculation of the spatial VA/Q inequality suggests there is no correlation with (A-a)Do2 reduction. In this paper we examine the influence of a nonionic micelle-forming surfactant, Triton X-100, on spherical, nonionic polymeric micelles composed of poly(butadiene)-co-poly(polyethylene oxide). Characterization of Chinese giant salamander iridovirus tissue tropism and inflammatory response after infection.

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The mutant virus acquired two amino acid mutations, Glu to Gly at position 170 and Ala to Glu 442 in fusion (F) glycoprotein, but no mutations in haemaggulutinin-neuraminidase (HN) glycoprotein. Humans have remarkable abilities in the dexterous use of tools to extend their physical capabilities. Conjugation of the phenol derived from rivastigmine with amphetamines gave access to novel carbamate cholinesterase inhibitors.

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The total amount of sphingolipid in scaly skin did not differ statistically from that in control skin. Nanoscale characterization of isolated individual type I collagen fibrils: polarization and piezoelectricity.

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This study evaluates the reliability of type 3 portable monitoring (PM) in a home setting. Suppression of glioma growth in vitro and in vivo by glia maturation factor. Such emerging strategies include a reduction/alteration of the lignin network to enhance polysaccharide accessibility, reduction of polymer derived processing inhibitors, and increases in polysaccharides with a high hexose/pentose ratio.

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Immunohistochemistry was used to evaluate the expression of PAs and PAIs in the salivary gland. A totally implantable venous access device is described and a step by step technique for implanting the device is given. Phagocytosis was analysed using immunoglobulin opsonised Escherichia coli. Delivery and neonatal outcome data were obtained from discharge summaries supplemented by individual chart review. A standardised interview method was used to elicit details of sexual abuse in a psychiatrically normal control group and samples of patients with anorexia nervosa, bulimia nervosa, or depression.

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In our previous study, a point mutation in Uba1, the gene encoding ubiquitin-activating enzyme, was identified in temperature-sensitive (ts) CHO-K1 mutant tsTM3 cells, which led to a Met-to-Ile substitution at amino acid 256 in Uba1 protein. Fifty-five lung cancer tissues, 32 paracancerous tissues and 32 normal lung tissues were collected.

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Range-specific exaggerations selectively emphasized emotional manner whereas domain-specific exaggerations of differences in duration did not. In this study we show that Niemann-Pick type C1 (NPC1) and Niemann-Pick type C2 (NPC2) mutants have increased cellular cholesterol, yet they are unable to suppress LDL receptor activity and cholesterol biosynthesis. This environmental cell also functions as a gaseous detector device. Previously, efforts using various sampling methods and techniques have resulted in limited success, due in part to the complicated dispersion pattern of the explosive particle residues upon detonation.

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LPC from burn serum induces pneumonedema in severe burn animal and may play a role in increasing vascular permeability to small molecules. Before and after treatment and 1 month posttreatment, patients filled in the Ulcer Esophagitis Subjective Symptoms Scale (UESS) and the Gastrointestinal Symptom Rating Scale (GSRS) for gastrointestinal symptoms and subjective health complaints (SHC) inventory for nongastrointestinal symptoms in addition to short form of the Nepean dyspepsia index (SF-NDI) for evaluation of QoL. These routines can be accessed via the command line, via a Java programming interface access or a basic graphical user interface. Clinical evaluation of side effects of current oral contraceptives. The spalt transcript accumulates to high levels in the segmental anlagen affected in mutant embryos but is also found in regions of the embryo where no functional requirement has been demonstrated.

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MRI diagnosis of spontaneous uterine rupture of an unscarred uterus. However, the trafficking of GluA2 in POCD and its underlying mechanism are not clear. Scyon Orthopaedics AG developed a new mode of cementless fixation of the femoral component that provides immediate and permanent anchorage by monocortical locking screws. Industries, at least in Europe, are allowed to choose their own independent protocol review board prior for approval.

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The results indicate that the time window of memory is a key factor in dissociating multiple memory systems. Identification and passivation of defects in self-assembled monolayers. Cultures of these ATL cells both produced endogenous IL-2 protein in the absence of added mitogen and proliferated at higher levels when exogenous recombinant IL-2 was added.

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An induction of antioxidant defence might play an important role for animals to adapt to micro-gravitational stress, possibly during actual space flights. The purpose of this study was to present a novel treatment method for repair of a type III endoleak due to separation of modular components of an AneuRx (Medtronic AVE, Sunnyvalle, CA) stent graft as a result of graft kinking. All patients with clinical and microbiological evidence of bacterial infection were treated with intravenous antibiotics.

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Pirenzepine and atropine caused a dose dependent inhibition of carbachol-stimulated pepsinogen secretion. When expressed in PC12 cells, the platelet-derived growth factor beta receptor (beta PDGF-R) mediates cell differentiation.

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Spontaneous bilateral bacterial empyema in a patient with nephrotic syndrome. Autophagy as measured by the expression of the microtubule-associated protein light chain 3-II (LC3-II) and autophagosome formation, and levels of AKT, ERK1/2, and mTOR activity to quantify the phosphorylation of AKT, ERK1/2, and S6K (the downstream target of mTOR). Treatment of isolated and multiple ligament injuries of the knee: anatomy, biomechanics, diagnosis, indications for repair, surgery The authors conclude that the use of a middle meatotomy for the surgical treatment of aspergillosis of the maxillary sinus makes it possible to assure complete resection, to adapt post-operative care and to permit prolonged aeration of the sinus.

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A reduction of the interparticle interactions is observed just 4 h after the beginning of the degradation process. Expression of glial fibrillary acidic protein in human medulloblastoma cells treated with recombinant glia maturation factor-beta. However, in humans GH deficiency (GHD) is not usually associated with immunodeficiency and only minor abnormalities of immune function have been reported, as compared to those observed in GHD animals.

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Salivary epidermal growth factor (EGF) is produced primarily by parotid glands. Difficulties with airway management continue to be a major cause of anesthesia-related morbidity, mortality, and litigation. To assess the role of early mid-trimester cervical length measurement as a predictor of spontaneous preterm birth in an unselected population. The Miller Assessment for Preschoolers (MAP) is a scale that can be used to evaluate preschool children with suspected preacademic problems. Many recent studies demonstrate that tight glucose control can decrease morbidity and mortality associated with critical illness.

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In recent years, new devices have been designed to improve the outcome of these procedures when an intracoronary thrombus is present. Therefore, an important new function for crmA is the inhibition of cytokine-induced apoptosis. Exposure and risk estimates from experimental plots or monitoring stations may require scaling factors if they are to be used for larger watersheds or regional analyses.

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In group-B, 13 patients were administered 40 mg of famotidine or 300 mg of nizatidine a day. PC12 is a rat pheochromocytoma cell line which has been increasingly used as a model system for both neural differentiation and chromaffin cell function. They give the insight into various connections between the particular intracellular compartments occurring at different developmental stages.

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Comparison between short- and long-term insulin-like growth factor response to recombinant human growth hormone. Dental Pipeline Program: a national program linking dental schools with the issue of access to care. Autopsy revealed the presence of two adult, partly digested common toads (Bufo bufo) in the stomach.

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As verified later, 78 of the patients had rheumatoid arthritis and 63 seronegative poly- or oligoarthritis, while one had systemic lupus erythematosus. Multichannel detection of magnetic compound action fields with stimulation of the index and little fingers.

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Cuticle of the proboscidian sheath in Glycera convoluta Keferstein. It has been associated with lack of empathy and emotional discomfort of physicians. 17beta-estradiol inhibits the production of interferon-induced protein of 10 kDa by human keratinocytes. PBDEs were detected in all the cetacean samples analyzed, and concentrations were one or two orders of magnitude lower than for PCBs and DDTs. Here we develop a quantum mechanical framework and apply first-principles calculations to study the energy distribution and scattering processes of HCs generated by SPPs in Au and Ag.

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Apoptosis is a well-organised process of cell death pre-programmed inside the cell. The sensitivity of the test was estimated to be 50 eggs in 5 g of faeces. Risk factors for accelerated atherosclerosis, responsible for ischemic cardiopathy and myocardial infarction, are both common factors (e.g., hypertension, tobacco smoking and diabetes) and factors more specific for the uremic state (e.g., dyslipidemia, hyperhomocysteinemia and oxidative stress), all of which also are amendable by proper therapy. We observed that docosahexaenoic acid (DHA) reverted the resistance of nr-HaCaT cells to UVR-induced apoptosis, increasing the Bax/Bcl-2 ratio and caspase-3 activity, and reduced COX-2 levels by inhibiting the expression of the human antigen R (HuR), a known COX-2 mRNA stabilizer in keratinocytes. Assessment of cardiac function in mice lacking the mitochondrial calcium uniporter.

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A 76-year-old male patient sought medical attention for a photodistributed rash and considerable muscular weakness present for one month. Whether in combination with laparoscopic-assisted or laparoscopic hysterectomy, laparoscopic staging, including lymph-node dissection, is a major component in the treatment of patients with early endometrial cancer. A simple method for selecting transgenic fish after transfer of the firefly luciferase gene was developed. Mitochondrial heteroplasmy, the occurrence of more than one mitochondrial haplotype within an individual, can be generated by relatively common somatic mutations within an individual, by heteroplasmy of the oocytes, or by paternal leakage of mitochondria during fertilization of an egg. EGF-R mRNA was detected at all stages of conceptus development analysed.

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Novel M2-associated markers were characterized and identified as genes controlling the extracellular metabolism of ATP to generate pyrophosphates (PPi). Cytomegalovirus seropositivity, infectious burden, and coronary artery disease. Mean BP decreased to 30 mm Hg by the combination of decreased CO and decreased vascular resistance. Histologic studies showed hypertrophy of the smooth muscle, a markedly reduced number of argyrophilic neurons, and degenerative changes of argyrophilic neurons and nerve fibers but without Schwann cell proliferation, intranuclear inclusions, or inflammatory cells. During central fixation, a blue or red target embedded in an array of grey distractors was presented for 250 ms in either the left or right visual hemifield.

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With this technique, it was demonstrated that the cross-linked albumin inhibited the adherence of Staphylococcus aureus and Staph. This article provides a chronological perspective on the development of knowledge concerning the neural control of renal function and is divided into three parts: the past, the present, and the future. Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats. However, in recent years, wear patterns have increasingly been observed on retrievals that cannot be replicated by the current standard.

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To examine lifestyle behaviors that may contribute to endometrial cancer survivor morbidity and to identify associations with quality of life. Hierarchical Bayesian spatial modelling of small-area rates of non-rare disease. Temperature dependence is observed for the curvature below the temperature of bijsluiter diclofenac 50 mg centrafarm zero spontaneous curvature, but the ternary system cannot produce reverse microemulsion as observed with classical C(i)E(j). The three AhHMA4 copies possess divergent promoter sequences, but highly conserved coding sequences, and display identical expression profiles in the root and shoot vascular system. Studies on glycolysis and ascorbic acid metabolism in different parts of the fruits of Citrus acida and changes in the same during maturation.

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The authors reviewed current knowledge regarding barriers to breast and cervical cancer screening and public education interventions that address them. This analysis suggested that the periplasmic loop comprises only three amino acid residues with the adjacent transmembrane helices at positions 361-387 and 393-416. We have developed a practical model for individualising the risk of adartrel 2 mg posologie arnica short-term readmission for CHF.

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Similar micromatrix particles were also produced with griseofulvin-loaded thermally oxidized mesoporous silicon (TOPSi) nanoparticles dispersed to the polymer micromatrices. The human epidermoid carcinoma-derived cell lines, A431 and HEp-2, which do not express tenascin-C by themselves in vitro, do express tenascin-C after transplantation into nude mice, and transforming growth factor beta 1 (TGF-beta 1) induces them indomethacin hydrocodone interactions with xanax to express tenascin-C in vitro. A different concept, an evolution, the influence of pedagogical trends: an assessment of the reform in progress. Total arch replacement for right aortic arch with Kommerell diverticulum and aberrant left subclavian artery Most patients with inflammatory bowel disease (IBD) undergo long-term outpatient follow up.

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The model and its selected parameters successfully described the main effects of the apparent mass phenomenon compared to experimental data documented in the literature. In summary, these data clomipramine for dogs aggression towards children suggest that AQP2-mediated water transport is downregulated not only by basolateral nucleotides, mediated by P2Y(2) receptors, but also by luminal nucleotides, mediated by P2X(2) and/or P2Y(4) receptors. This restraint on the substrate binding site provides a molecular explanation for the observed dependence between coenzyme and substrate chemical structures. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.

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Moreover, serious complications are possible after BCG-vaccine administration in seriously immunocompromised children. During the reaction ferrylMb was reduced to metmyoglobin (metMb) by BSA, myoglobin-binding BSA was formed, and there was a rapid loss of SH enzyme inactivity. dicloberl 100 mg dawkowanie morfiny Two main mechanisms seem at play in T cell-mediated cytotoxicity, a process in which target cell death often follows an apoptotic cell death pattern.

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Further, they have provided exploratory lexinor norfloxacin 400mg treatment results which gave rise to the following interpretations: Auditory spaciousness is a multidimensional perceptual attribute, predominantly caused by early lateral reflections. Plaque formation and intima-medial thickness (IMT) were measured using B-mode carotid Doppler scan. In physiological salt solution (PSS) which mimicks the cardiac cells cytoplasm and contains 120 mM K-MES, 10 mM NaCl, 20 mM imidazole, pH 7.2, 20 mM taurine, 15 mM creatine, 15 mM Na2phosphocreatine, 5 mM Na2ATP, 8 mM MgCl2, 5 mM K2HPO4, 3 mM glutamate, 3 mM malate, 0.5 mM dithiothreitol and 10 mg/ml of bovine serum albumine both isolated mitochondria and intracellular structures in skinned fibers stay intact. Elicitor contact and artificial acidification mutually desensitized the cells for either signal.

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Dependence on acceptor type and on enrichment of cells with cholesterol. In normal skin, AR was consistently localized wycofano fervex ingredients in seboblasts and in some differentiated sebocytes, and variable expression was seen in luminal epithelial cells of eccrine and apocrine glands in the secretory portion.

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Recent studies have demonstrated that certain types of necrosis are regulated and programmed dependent on the activation of receptor-interacting serine/threonine-protein kinase (RIPK) 1 and 3 which may be negatively regulated by Fas-associated protein with death domain (FADD). In this study, we investigated whether some of the benzodiazepines would influence L-tryptophan binding to rat hepatic nuclei or nuclear envelopes as assayed by in vitro L-(5-3H) tryptophan binding. Evidence for potassium carbonate crystallites on air-cleaved mica surfaces. The scavenger activities of gallic acid, 5-O-galloyl, 3,5-O-digalloyl, 3,4,5-O-trigalloyl quinic acid derivatives, have been estimated against 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, superoxide (O2) radical, and hydroxyl (OH) radical. accidental double dose of augmentin in dogs After SDS-polyacrylamide gel electrophoresis distinct differences were observed, indicating that the protein and glycoprotein profiles of the distal intestine are less complex.

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We will outline the advances in virotherapy in the treatment of ovarian cancer, with particular attention directed toward adenoviral vectors. The impact of unmeasured mechanism of action of tacrolimus in vitiligo model baseline effect modification on estimates from an inverse probability of treatment weighted logistic model.

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The quantification limit for TCA and TBA in wine was lowered substantially using GC-HRMS in emidoxyn drug test combination with the optimized SPME method and allowed the detection of low analyte concentrations (ng L(-1)) with good accuracy. Torsades de pointes: a characteristic spectral pattern in sudden cardiac death.